As of Dec. 6, 2016 Novartis and Ariad announced research updates
In Phase III study by Novartis on Zykadia® (ceritinib) as a first-line treatment, they found a 45% reduction in the risk of disease progression. The study found a median progression free survival (PFS) of 16.6 months for all patients taking ceritinib, compared with 8.1 months for patients treated using just chemotherapy. Also reported an ORR of 72.5%, compared with 26.7% for chemotherapy patients. Patients with no brain metastases had a median PFS of 26.3 months with Zykadia compared with 8.3 months for standard chemotherapy.
Ariad had positive info from a Phase I/II study and a pivotal phase 3 ALTA trial studying brigatinib, in patients with brain metastases. Patients with brain mets had an ORR was 53% in the Phase I/II trial.
The patients previously treated with Crizotinib and with brain mets had an ORR of 67% in the higher dose arm B of the ALTA trial. Median brain mets PFS in Arm B was 18.4 months.