MPDL3280A Breakthrough therapy for ALK resistance

Anti–PD-L1 agent MPDL3280A has received a breakthrough therapy designation from the FDA as a potential treatment for patients with PD-L1–positive non–small cell lung cancer (NSCLC) who have progressed on platinum-based chemotherapy and a EGFR or ALK inhibitor. MPDL3280A is developed by Roche. IV infusion every 3 weeks.

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