Category Archives: Anaplastic Large-Cell Lymphomas

Update on Novartis and Ariad trials

As of Dec. 6, 2016 Novartis and Ariad announced research updates In Phase III study by Novartis on Zykadia® (ceritinib) as a first-line treatment, they found a 45% reduction in the risk of disease progression. The study found a median progression free survival … Continue reading

Posted in Anaplastic Large-Cell Lymphomas, AP26113 - brigatinib from Ariad, Brain metastases, ceritinib - Zykadia from Novartis, Lung cancer, Potential Treatments, Research | Leave a comment

ap26113 resistance in lymphoma

Several NPM-ALK resistant mutatations were identified in the lab. They provide targets for future research. http://www.ncbi.nlm.nih.gov/pubmed/25421750

Posted in Anaplastic Large-Cell Lymphomas, AP26113 - brigatinib from Ariad, Research, Resistance to treatment | Leave a comment

Treatment potential in Lymphomas

Effectivness of ASP3026 (which is no longer in clinical trials for this disease) was tested on NPM-ALK in lymphomas with positive results. http://impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=2170&path%5B%5D=3439

Posted in Anaplastic Large-Cell Lymphomas, ASP3026 from Astellas, Potential Treatments, Research | Leave a comment

What causes ALK+ lung cancer?

Someone recently posted this question on Inspire.com. Here was my reply. I have wondered about this for a while. I recently found some information others may find interesting. I do not know if any of the following applies to ROS+ … Continue reading

Posted in Anaplastic Large-Cell Lymphomas, Lung cancer, Neuroblastomas, Research | Leave a comment

Interesting articles

Here is a link to a article about the science related to the ALK gene and protean and how that fits with the development of ALK inhibitors. It includes a chart on the estimated number of patients who develop different … Continue reading

Posted in Anaplastic Large-Cell Lymphomas, Lung cancer, Research, Resistance to treatment | Leave a comment

Treating Pediatric Cancers

Here is a link to an article about the surprising success of using Crizotinib to treat three pediatric cancers (anaplastic large cell lymphoma(ALCL), inflammatory myofibroblastic tumors, and neuroblastomas). For example, 88% of the treated ALCL Patients experienced a complete response … Continue reading

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Articles about numerous potential ALK inhibitor drugs

These articles are overview or summary articles that discuss 3 of more potential drugs that may inhibit the growth of ALK + tumours.

Posted in Anaplastic Large-Cell Lymphomas, Potential Treatments, Research | Tagged , | 4 Comments

Other Drugs

A place to post info on other potential drugs for which there is no specific page or for posting research that covers two or more different drugs.

Posted in Anaplastic Large-Cell Lymphomas, Glioblastomas, Lung cancer, Neuroblastomas, Potential Treatments, Research | Tagged | 23 Comments

Research on drugs from Teva (formerly Cephalon)

This page is for tracking research by Teva (formerly Cephalon), including CEP-37440, CEP-28122, CEP-14083, CEP-14513, and compound “15”. There are several research articles by Cephalon and they refer to different drugs using different names so it is unclear when different articles are talking about the same drug … Continue reading

Posted in Anaplastic Large-Cell Lymphomas, Neuroblastomas, Potential Treatments, Research | 12 Comments