Category Archives: lorlatinib – Lorbrena by Pfizer

Loralatinib phase II results

Posted on March 1, 2019 by admin

Published on 11-6-18, I believe in conjunction with the FDA approval. 276 ALK+ & ROS1+ patients. But only adverse events were reported for the ROS1 patients The description of the results in the article I found was very confusing. The … Continue reading →

Posted in Brain metastases, lorlatinib - Lorbrena by Pfizer, Lung cancer, Potential Treatments, Research | Leave a comment

Patients can live a median of 6.8 years after stage 4 diagnosis

Posted on February 13, 2019 by admin

A study of 110 patients at the University of Colorado found that 50% of patients live 6.8 years or longer. These were patients who had access to multiple ALK inhibitors through clinical trials at that research University. That University also … Continue reading →

Posted in alectinib - Alecensa from Chugai - Roche - GenenTech, brigatinib-Alunbrig from Takeda, ceritinib - Zykadia from Novartis, crizotinib - Xalkori from Pfizer, lorlatinib - Lorbrena by Pfizer, Lung cancer, Research | Leave a comment

FDA conditionally approves Loralatinib

Posted on November 3, 2018 by admin

As of 11-2-2018 the FDA conditionally approved Loralatinib. It’s brand name is Lorbrena. The approval is for Loralatinib treatment for patients: 1) as a third line after crizotinib and one other ALK inhibitor (basically Brigatinib), or 2) as a second line treatment … Continue reading →

Posted in alectinib - Alecensa from Chugai - Roche - GenenTech, Brain metastases, brigatinib-Alunbrig from Takeda, ceritinib - Zykadia from Novartis, crizotinib - Xalkori from Pfizer, lorlatinib - Lorbrena by Pfizer, Lung cancer, Potential Treatments, Regulatory applications & approvals | Leave a comment

Impact of EML4-ALK Variants on resistance

Posted on June 15, 2018 by admin

As of April 20, 2018 Study of 2 groups of patients. Group A = 129 patients, Group B = 577 patients. The most frequent variants were Variant 1 (43%) and Variant 3 (40%). “ALK resistance mutations were significantly more common … Continue reading →

Posted in lorlatinib - Lorbrena by Pfizer, Lung cancer, Potential Treatments, Research, Resistance to treatment | Leave a comment

Phase 1 & 2 full results for Lorlatinib

Posted on June 15, 2018 by admin

As of Oct. 16, 2017 Pfizer presented a Press release associated with a presentation at IASLC on Phase 2 results for 275 patients. All following are for ALK+ patients except where Ros1 is indicated Treatment Naive: ORR 90%; IC-ORR 75% Prior … Continue reading →

Posted in Brain metastases, lorlatinib - Lorbrena by Pfizer, Lung cancer, Potential Treatments, Research, Side Effects | Leave a comment

Great page with very high quality info on AlK & AlK inhibitors

Posted on June 16, 2017 by admin

Below is a link to a page that provides comprehensive regularly updated info written by two ALK research oncologists Dr. Alice Shaw and Ben Solomon, Phd (then edited by three people). It is written for an audience of doctors and … Continue reading →

Lorlatinib granted breakthrough therapy status

Posted on June 6, 2017 by admin

On April 27, 2017, the FDA granted Pfizer Breakthrough Status on lorlatinib for patients previously treated with one or more ALK inhibitors. So you don’t have to take Crizotinib first, any of the other 3 will do. Also a Phase … Continue reading →

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Outcomes for ALK+ patients

Posted on May 22, 2016 by admin

Abstract e20550 is from Spain and involves 49 patients. Patients took 6 different ALK inhibitors. The abstract concluded “ALK+ patients who received targeted agents have prolonged survival despite brain metastases…. ALK inhibitors improve intracranial response rate and survival.”

Lorlatinib abstract

Posted on May 19, 2016 by admin

Abstract 9009 is a phase 1 dose escalation trial (dose levels ranged from 10-200 mg and the Recomended phas 2 dose was 100 mg once daily). There were 54 patients as of November 30, 2015. 41 are ALK positive and … Continue reading →

Posted in Brain metastases, lorlatinib - Lorbrena by Pfizer, Lung cancer, Potential Treatments, Research, Resistance to treatment, Side Effects | Leave a comment

Upcoming ASCO abstracts

Posted on May 18, 2016 by admin

There are 14 abstracts for the upcoming ASCO that have ALK in the title. But only 6 look like they are likely to be broadly applicable to people on this board. I will be posting summaries over the next week … Continue reading →

Posted in alectinib - Alecensa from Chugai - Roche - GenenTech, Brain metastases, brigatinib-Alunbrig from Takeda, crizotinib - Xalkori from Pfizer, lorlatinib - Lorbrena by Pfizer, Lung cancer | Leave a comment