Category Archives: crizotinib – Xalkori from Pfizer

Alectinib approved by FDA

The FDA conditionally approved alectinib (brand name Alecensa) on December 11, 2015 as a second line treatment. This approval came less than 3 months after the FDA application was filed. The approval was based on results from two single-arm clinical trials. … Continue reading

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Editorial on Brain mets and ALK lung cancer

The Journal of Clinical Oncology has an editorial about the current research on treating brain mets for ALK+ patients that discusses ALK inhibitors and different kinds of radiation treatments. Treatments discussed include: 1) Crizotinib, 2) Ceritinib 3) Alectinib 4) brigatinib, … Continue reading

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European Commission expands use of Crizotinib

Around 12-2-2015 the Europe Commission approved Xalkori (Crizotinib) as a first line treatment so it can be given before chemotherapy.

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Survey of ALK inhibitors effects on brain mets

This survey summarizes the results of other research to describe the current level of knowledge about how effective different ALK inhibitors are at treating brain mets. Inhibitors that are discussed include crizotinib, ceritinib, alectinib, AP26113 (brigatinib) and PF-06463922 (lorlatinib). http://www.thecco.net/article/view/6520/7543

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Comparison of different diagnostic tests

A comparison of the Fluorescence in-situ hybridization (FISH) test and ALK immunohistochemistry (IHC) for determining ALK + status. Basically the tests have results that are 99% consistent. The authors argue that either test should be sufficient on its own to determine … Continue reading

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2 abstracts on Crizotinib

Please see glossary for definitions of acronyms. Abstract 19135 is a survival comparison study of 3 ways of detecting the ALK fusion gene. This study was done in China and involved 75 (and possibly 98 patients). The abstract refers to … Continue reading

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Novartis update

On May 8, 2015 Novartis announced that Zykadia (ceritinib) was approved by the European Commission to treat ALK+ lung cancer patients previously treated with Crizotinib.

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Crizotinib followed by Ceritinib

A retrospective study of 73 patients who took Crizotinib followed by Ceritib  from 4 hospitals found positive results. The median progression free survival (PFS) on Crizotinib was 8.2 months. The median interval before starting Ceritinib was 25 days. The median … Continue reading

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Pfizer update

Pfizer announced that in 2015 the are going to start trials that combine imunitherapy (PDL-1 and PD-1) drugs with its two ALK inhibitor drugs. Pfizer is planning a potential pivotal study of PF-06463922 starting in 2015. By the end of … Continue reading

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Video on Alectinib

Here is a video discussing Alectinib and comparing it with Crizotinib and Ceritinib. He also mentioned an upcoming trial that is being planned that would compare various sequences of the drugs. http://www.onclive.com/conference-coverage/thoracic-2014/Dr-Govindan-on-the-Potential-for-Alectinib

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