Category Archives: Uncategorized

Next-generation ALK inhibitors & brain mets

Here is an article on a presentation by Dr. Ou on potential ALK inhibitor treatments for brain metastases http://www.onclive.com/conference-coverage/ilcc-2014/Next-Generation-ALK-Inhibitors-Effective-in-Patients-With-Brain-Metastases

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Video on 2nd generation ALK inhibitors

Here is the link for the video by OncLive. https://m.youtube.com/watch?v=UAYcOohlRcI

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Acquired Resistance in Lung Cancer

This article in Nature covers EGFR and ALK mutations and resistance mechanisms. http://www.nature.com/nrclinonc/journal/vaop/ncurrent/abs/nrclinonc.2014.104.html

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Ariad AP26113 ASCO update

71 ALK+ NSCLC patients enrolled out of 125 patients. Main adverse event of concern is early onset pulmonary (lung) symptoms. Out of 125 patients this happened 10% and occurred most frequently at doses of 180 mg or higher. New protocol: … Continue reading

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Two interesting trial from the world of EGFR mutations

Genentech/Roche has recently done two studies involving Avastin and Erlotinib. In November 2013 they released a study of over 1,100 patients comparing Avastin with and without Erlotinib. Critically I believe that the patients were not screened for the EGFR mutation. … Continue reading

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Uptodate.com updated as of early May

Uptodate’s entry on ALK inhibitors was updated in early May on Ceritinib’s FDA approval.

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New ALK inhibitor – OTX015

Oncoethix, a European consortium, has published a presentation on preclinical results for a new ALK inhibitor called OTX015. When combined with Crizotinib it has greater inhibitory effect. It also inhibits: BET and BRD families of reader proteans. The BET inhibition … Continue reading

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Potential causes of resistance to various ALK inhibitors

This post will cover various articles on possible causes of developed resistance.

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Radiation to treat resistant tumors

This post will include links to articles about the treatment of tumors that have developed resistance to a targeted therapy.

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Disease Flare

This post is for links to articles about disease flare (the rapid increase in cancerous growth after a kinase inhibitor is discontinued).

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